• Curr Opin Invest Dr · Jan 2008

    Review

    Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects.

    • Florian M Reichle and Peter F Conzen.
    • Ludwig-Maximilians-University, Department of Anesthesiology and Intensive Care Medicine, Nussbaumstrasse 20, 80336, Munich, Germany. Florian.Reichle@med.uni-muenchen.de
    • Curr Opin Invest Dr. 2008 Jan 1;9(1):90-100.

    AbstractProgenics Pharmaceuticals Inc and Wyeth Pharmaceuticals are developing methylnaltrexone, a micro-receptor opioid antagonist derived from naltrexone by the addition of a methyl group. The intravenous formulation of methylnaltrexone is currently in phase III clinical trials for the potential treatment of postoperative ileus.

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