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Journal of neurosurgery · Jan 2017
ReviewConvection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.
- Arman Jahangiri, Aaron T Chin, Patrick M Flanigan, Rebecca Chen, Krystof Bankiewicz, and Manish K Aghi.
- Department of Neurological Surgery, University of California at San Francisco, San Francisco, California.
- J. Neurosurg. 2017 Jan 1; 126 (1): 191-200.
AbstractGlioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.
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