• Charles H Brown, Candice Morrissey, Masahiro Ono, Gayane Yenokyan, Ola A Selnes, Jeremy Walston, Laura Max, Andrew LaFlam, Karin Neufeld, Rebecca F Gottesman, and Charles W Hogue.
• Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
• J Am Geriatr Soc. 2015 Jan 1;63(1):16-23.

ObjectivesTo determine the prevalence of impaired olfaction in individuals presenting for cardiac surgery and the independent association between impaired olfaction and postoperative delirium and cognitive decline.DesignNested prospective cohort study.SettingAcademic hospital.ParticipantsIndividuals undergoing coronary artery bypass, valve surgery, or both (n = 165).MeasurementsOlfaction was measured using the Brief Smell Identification Test, with impaired olfaction defined as an olfactory score below the fifth percentile of normative data. Delirium was assessed using a validated chart review method. Cognitive performance was assessed using a neuropsychological testing battery at baseline and 4 to 6 weeks after surgery.ResultsImpaired olfaction was identified in 54 of 165 participants (33%) before surgery. Impaired olfaction was associated with greater adjusted risk of postoperative delirium (relative risk = 1.90, 95% confidence interval = 1.17-3.09, P = .009). There was no association between impaired olfaction and change in composite cognitive score in the overall study population.ConclusionImpaired olfaction is prevalent in individuals undergoing cardiac surgery and is associated with greater adjusted risk of postoperative delirium but not cognitive decline. Impaired olfaction may identify unrecognized vulnerability to postoperative delirium in individuals undergoing cardiac surgery.© 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

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