• Roger E Thomas, Tom Jefferson, and Toby J Lasserson.
• Department of Family Medicine, University of Calgary Medical Clinics North Hill, University of Calgary, 1707-1632 14 Avenue NW, Calgary, Canada T2M1M1. rthomas@ucalgary.ca
• Vaccine. 2010 Dec 16;29(2):344-56.

AimTo identify studies of influenza vaccination of HCWs and influenza in elderly residents in long-term care facilities.ScopeWe searched seven electronic databases for randomised controlled trials (RCTs) and non-RCTs. Two reviewers independently extracted data and assessed trial quality.ConclusionsThe key outcomes are serologically proven influenza, pneumonia, and deaths from pneumonia, and pooled data from three C-RCTs showed no effect. Pooled data from three C-RCTs showed lower resident all-cause mortality, but as influenza constituted less than 10% of all deaths even in epidemic years we question the appropriateness of this outcome measure. Pooled data from three C-RCTs showed vaccination of HCWs reduced ILI and data from one C-RCT that HCW vaccination reduced GP consultations for ILI, but as influenza constitutes less than 25% of ILI and we did not show that HCW influenza vaccination reduced serologically proven influenza we question whether this effect is due to confounding.Copyright © 2010 Elsevier Ltd. All rights reserved.

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