• Jing Fang, Weihong Yan, Guo-Xin Jiang, Wei Li, and Qi Cheng.
• Department of Neurology, Ruijin Hospital, School of Public Health, Shanghai Jiao Tong University, 227 South ChongQing Road, Shanghai 200025, China.
• Stroke. 2011 May 1;42(5):1461-3.

Background And PurposeWe sought to compare the distribution of the serotonin transporter gene SLC6A4 polymorphism between depressed and nondepressed poststroke patients.MethodsPatients with cerebral stroke admitted to hospital during a 1-year period were enrolled in a 1:1 case-control study. All cases and controls were genotyped for polymorphism of the serotonin transporter-linked promoter region and the single-nucleotide polymorphism rs25531.ResultsAmong 367 patients with cerebral stroke, 57 (15.5%) were diagnosed with poststroke depression at 1 month after stroke. In the patients with poststroke depression, 7 genotypes of the serotonin transporter gene SLC6A4 were detected, and the frequency of S/S homozygotes was significantly higher (P=0.049) than that in controls.ConclusionsS/S homozygosity may be positively associated with the occurrence of poststroke depression in Chinese patients.

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