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- J Noda, S Umeda, T Arai, A Harima, and K Mori.
- Department of Anesthesiology, Faculty of Medicine, Kyoto University, Japan.
- Clin J Pain. 1989 Jun 1; 5 (2): 147-52.
AbstractThe continuous subcutaneous infusion of buprenorphine, a new approach to the relief of severe cancer pain, has been carried out using a portable infusion pump. The efficacy of this method was examined in 30 patients by visual analogue scale. An infusion rate of 4 micrograms/kg/day following intramuscular administration of 0.004 micrograms/kg gave satisfactory pain relief without serious complications. The minimum effective blood concentration was not detectable by high-performance liquid chromatography. Advantages of this therapy are its simplicity, applicability in many types of cancer, multiple sites of administration, and easier training on the part of health personnel.
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