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Pediatric transplantation · Dec 2007
Case ReportsAcyclovir-resistant herpes simplex virus pneumonia post-unrelated stem cell transplantation: a word of caution.
- Haydar Frangoul, Marcia Wills, Christine Crossno, Michael Engel, and Jennifer Domm.
- Pediatric Stem Cell Transplant Program, Vanderbilt Children's Hospital, Nashville, TN 37232, USA. haydar.frangoul@vanderbilt.edu
- Pediatr Transplant. 2007 Dec 1;11(8):942-4.
AbstractHSV causes serious complications in immunocompromised patients, especially SCT recipients. Although ACV is an effective antiviral prophylaxis, the emergence of ACV resistance is a growing problem. The authors describe two cases of fatal ACV-resistant HSV in two pediatric patients following unrelated donor SCT. Despite the in vitro sensitivity of the HSV isolates to foscarnet, both patients failed to respond to foscarnet therapy. Other antiviral therapies should be considered in those patients who fail to show rapid clinical improvement.
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