• Exp Brain Res · Mar 2004

    Excitability of the Adelta nociceptive pathways as assessed by the recovery cycle of laser evoked potentials in humans.

    • A Truini, P Rossi, F Galeotti, A Romaniello, M Virtuoso, C De Lena, M Leandri, and G Cruccu.
    • Department of Neurological Sciences, University "La Sapienza", Viale Università 30, 00185, Rome, Italy.
    • Exp Brain Res. 2004 Mar 1;155(1):120-3.

    AbstractTo investigate the excitability of Adelta nociceptive pathways and the nature of the vertex laser evoked potentials (LEPs), we studied the recovery cycle of the P2-LEP component and compared it with that of the P200 of the somatosensory evoked potential (SEP). Using two identical CO(2)-laser stimulators, we delivered paired stimuli to two adjacent skin spots on the hand at interstimulus intervals ranging from 250 ms to 2 s. The test P2-LEP was strongly inhibited at the 250-ms interstimulus interval ( P<0.01) and progressively recovered by the 2-s interval. The P200-SEP, after paired stimuli to the median nerve, showed a time course even slower than the P2-LEP ( P<0.01). Besides providing the LEP recovery curve in normal subjects, our findings indicate that the P2-LEP relays through a number of synapses similar to (or even lower than) that for the P200-SEP, thus lending further support to the view that the nociceptive P2-LEP is not an endogenous potential equivalent to the P300.

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