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- M Ringkamp, Y B Peng, G Wu, T V Hartke, J N Campbell, and R A Meyer.
- Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA.
- J. Neurosci. 2001 Jun 15;21(12):4460-8.
AbstractThe recently cloned vanilloid receptor (VR1) is postulated to account for heat and capsaicin sensitivity in unmyelinated afferents. We sought to determine whether heat and capsaicin sensitivity also coexist in myelinated nociceptive afferents. Action potential (AP) activity was recorded from single A-fiber nociceptors that innervated the hairy skin in monkey. Before intradermal injection of capsaicin (10 microg/10 microl) into the receptive field, nociceptors were classified as heat-sensitive (threshold,
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