• Physiology · May 2013

    Review

    Nogo-A represses anatomical and synaptic plasticity in the central nervous system.

    • Anissa Kempf and Martin E Schwab.
    • Brain Research Institute, University of Zurich, Switzerland. kempf@hifo.uzh.ch
    • Physiology (Bethesda). 2013 May 1;28(3):151-63.

    AbstractNogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS.

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