• Nephron. Physiology · Jan 2014

    Central venous oxygen saturation: a potential new marker for circulatory stress in haemodialysis patients?

    • Laura E A Harrison, Nicholas M Selby, and Christopher W McIntyre.
    • Department of Renal Medicine, Royal Derby Hospital, Derby, UK.
    • Nephron Physiol. 2014 Jan 1;128(1-2):57-60.

    Background/AimsHaemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required.MethodsIntra-dialytic central venous oxygen saturation (ScvO2) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients.ResultsPre-dialysis ScvO2 was 63.5 ± 13% and fell significantly to 56.4 ± 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO2 (r = -0.680, p = 0.015).ConclusionsThis initial study demonstrates ScvO2 sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.

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