• Sam Parnia, Jie Yang, Robert Nguyen, Anna Ahn, Jiawen Zhu, Loren Inigo-Santiago, Asad Nasir, Kim Golder, Shreyas Ravishankar, Pauline Bartlett, Jianjin Xu, David Pogson, Sarah Cooke, Christopher Walker, Ken Spearpoint, David Kitson, Teresa Melody, Mehboob Chilwan, Elinor Schoenfeld, Paul Richman, Barbara Mills, Nancy Wichtendahl, Jerry Nolan, Adam Singer, Stephen Brett, Gavin D Perkins, and Charles D Deakin.
• 1Resuscitation Research Group, State University of New York at Stony Brook, Stony Brook, NY.2Department of Resuscitation Services, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom3NIHR Respiratory BRU, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.4Department of Anaesthesia and Critical Care, Queen Alexandra Hospital, Portsmouth, United Kingdom.5Centre for Peri-Operative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom.6Department of Critical Care Medicine, Warwick Medical School and Heart of England NHS Foundation Trust, Birmingham, United Kingdom.7Department of Anaesthesia and Critical Care, Royal United Hospital, Bath, United Kingdom.
• Crit. Care Med. 2016 Sep 1; 44 (9): 1663-74.

ObjectivesCardiac arrest is associated with morbidity and mortality because of cerebral ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation during resuscitation is associated with improved return of spontaneous circulation, survival, and neurologic outcomes at hospital discharge. We further examined the validity of regional cerebral oxygenation as a test to predict these outcomes.DesignMulticenter prospective study of in-hospital cardiac arrest.SettingFive medical centers in the United States and the United Kingdom.PatientsInclusion criteria are as follows: in-hospital cardiac arrest, age 18 years old or older, and prolonged cardiopulmonary resuscitation greater than or equal to 5 minutes. Patients were recruited consecutively during working hours between August 2011 and September 2014. Survival with a favorable neurologic outcome was defined as a cerebral performance category 1-2.InterventionsCerebral oximetry monitoring.Measurements And Main ResultsAmong 504 in-hospital cardiac arrest events, 183 (36%) met inclusion criteria. Overall, 62 of 183 (33.9%) achieved return of spontaneous circulation, whereas 13 of 183 (7.1%) achieved cerebral performance category 1-2 at discharge. Higher mean ± SD regional cerebral oxygenation was associated with return of spontaneous circulation versus no return of spontaneous circulation (51.8% ± 11.2% vs 40.9% ± 12.3%) and cerebral performance category 1-2 versus cerebral performance category 3-5 (56.1% ± 10.0% vs 43.8% ± 12.8%) (both p < 0.001). Mean regional cerebral oxygenation during the last 5 minutes of cardiopulmonary resuscitation best predicted the return of spontaneous circulation (area under the curve, 0.76; 95% CI, 0.69-0.83); regional cerebral oxygenation greater than or equal to 25% provided 100% sensitivity (95% CI, 94-100) and 100% negative predictive value (95% CI, 79-100); regional cerebral oxygenation greater than or equal to 65% provided 99% specificity (95% CI, 95-100) and 93% positive predictive value (95% CI, 66-100) for return of spontaneous circulation. Time with regional cerebral oxygenation greater than 50% during cardiopulmonary resuscitation best predicted cerebral performance category 1-2 (area under the curve, 0.79; 95% CI, 0.70-0.88). Specifically, greater than or equal to 60% cardiopulmonary resuscitation time with regional cerebral oxygenation greater than 50% provided 77% sensitivity (95% CI,:46-95), 72% specificity (95% CI, 65-79), and 98% negative predictive value (95% CI, 93-100) for cerebral performance category 1-2.ConclusionsCerebral oximetry allows real-time, noninvasive cerebral oxygenation monitoring during cardiopulmonary resuscitation. Higher cerebral oxygenation during cardiopulmonary resuscitation is associated with return of spontaneous circulation and neurologically favorable survival to hospital discharge. Achieving higher regional cerebral oxygenation during resuscitation may optimize the chances of cardiac arrest favorable outcomes.

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