• Toshiya Shiga, Zen'ichiro Wajima, Tetsuo Inoue, and Ryo Ogawa.
• Department of Anesthesia, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
• J Clin Anesth. 2004 Nov 1;16(7):493-8.

Study ObjectivesTo examine whether prophylactic, atomized lidocaine blunts hyperdynamic responses and catecholamine release after an abrupt increase in volatile anesthetic administration.DesignProspective, randomized, double-blind, placebo-controlled study.SettingUniversity-affiliated hospital.Patients22 ASA physical status I adult patients scheduled for elective surgery.InterventionsPatients were randomly assigned to the saline or lidocaine group, and abruptly inhaled 5% isoflurane (4.3 MAC) after inhalation of ultrasonically nebulized lidocaine or saline via endoscopy mask. An esophageal Doppler probe was inserted via the mask to assess global hemodynamic performance.Measurements And Main ResultsImmediately after abrupt inhalation of isoflurane, heart rate (HR) in the saline group increased significantly and mean arterial pressure (MAP) remained unchanged, whereas HR in the lidocaine group remained unchanged, and MAP decreased significantly. No significant differences were noted between the saline and lidocaine groups in aortic blood flow, stroke volume in the aorta, total systemic vascular resistance in the aortic circuit, or aortic diameter. The plasma norepinephrine concentration increased in both groups after isoflurane inhalation, significantly so in the saline group but not in the lidocaine group.ConclusionProphylactic ultrasonically nebulized lidocaine (2 mg/kg) obtunds the hyperdynamic responses to abrupt inhalation of 5% isoflurane but does not completely block catecholamine release.

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