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J Parenter Sci Technol · May 1990
Quantitative evaluation of the stability and delivery of interleukin-1B by infusion.
- G C Visor, K P Tsai, J Duffy, M D Miller, T Calderwood, and V M Knepp.
- Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California.
- J Parenter Sci Technol. 1990 May 1;44(3):130-2.
AbstractThe stability and delivery of IL-1 beta has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion bags, at concentrations ranging from 100 ng/mL to 1 microgram/mL. At higher concentrations (1 microgram/mL), minimal drug loss was observed in both systems. At low doses (100 ng/mL) in the syringe-pump system, the addition of 1% human serum albumin was necessary to prevent significant drug absorption to the polypropylene drug reservoir.
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