• Anesthesia and analgesia · Jul 2006

    Randomized Controlled Trial

    Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery.

    • Maurizia Capuzzo, Barbara Zanardi, Elisa Schiffino, Cosimetta Buccoliero, Daniela Gragnaniello, Stefano Bianchi, and Raffaele Alvisi.
    • Department of Surgical, Anesthetic and Radiological Sciences, Section of Anesthesiology and Intensive Care, University Hospital of Ferrara, Ferrara, Italy. cpm@unife.it
    • Anesth. Analg. 2006 Jul 1;103(1):121-3, table of contents.

    AbstractMelatonin has been reported to reduce preoperative anxiety. We performed this study to compare preoperative anxiety in elderly patients receiving melatonin (M) or placebo (P). Anxiety was measured in patients aged >65 yr by a numerical rating scale (range, 0-10). Each patient was randomized to receive M 10 mg or P orally: 71 patients were in group P and 67 in group M. The median (quartiles) anxiety level was 5 (2-8) before and 3 (1-7) 90 min after premedication in group M and 5 (3-6) and 3 (1-5) in group P, respectively. M and P reduce anxiety in elderly patients to a similar degree.

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