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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain.
- S Petersen-Felix, M Luginbühl, T W Schnider, M Curatolo, L Arendt-Nielsen, and A M Zbinden.
- Department of Anaesthesiology and Intensive Care, University Hospital of Bern, Switzerland.
- Br J Anaesth. 1998 Nov 1;81(5):742-7.
AbstractWe have compared the analgesic potency of MAC-equivalent concentrations of xenon (10, 20, 30 and 40%) and nitrous oxide (15, 30, 45 and 60%) in humans using a multimodal experimental pain testing and assessment technique. We tested 12 healthy volunteers in a randomized, single-blind, crossover study. The following experimental pain tests were used: nociceptive reflex to repeated stimuli; pain tolerance to maximal effort tourniquet ischaemia; electrical stimulation; mechanical pressure; and cold. Reaction time was also measured. Xenon and nitrous oxide produced analgesia to ischaemic, electrical and mechanical stimulation, but not to cold pain. There was no difference in MAC-equivalent concentrations of xenon and nitrous oxide. Both increased reaction time in a similar manner. Xenon and nitrous oxide evoked nausea and vomiting in a large number of volunteers.
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