• M T van Rens, A B de la Rivière, H R Elbers, and J M van Den Bosch.
• Departments of Pulmonary Diseases, Sint Antonius Hospital, Nieuwegein, The Netherlands.
• Chest. 2000 Feb 1; 117 (2): 374-9.

Study ObjectivesStaging and classification in lung cancer are important for both patient management and clinical research. Results of survival after resection in patients with primary non-small cell lung cancer (NSCLC) are analyzed in order to validate recent refinements of the staging system.DesignRetrospective study; period from 1970 to 1992; follow-up > or = 5 years.PatientsA total of 2,361 previously untreated patients who underwent resection for stage I, II, or IIIA primary NSCLC.MeasurementsSurvival was estimated from the date of operation using the Kaplan-Meier survival analysis method. Deaths within 30 days of operation were excluded. Survival comparisons of different surgical-pathologic TNM classification (based on pathologic examination of resected specimens) as well as further discriminative factors were analyzed by log-rank test.ResultsPostoperative death occurred in 3.9% of patients. For survival analyses, 2,263 patients were included. The overall 5-year survival was 937/2,263 (41.4%). Five-year survival in stage IA was 255/404 (63%); in stage IB, 367/797 (46%); in stage IIA, 43/83 (52%); in stage IIB, 210/642 (33%); and in stage IIIA, 63/337 (19%). No significant difference in survival was demonstrated between stages IB and IIA. Until 4 years after surgery, age at operation did not influence survival; after 5 years, patients > 65 years old had a significantly lower survival.ConclusionThe TNM staging system accurately reflects the prognosis in primary NSCLC, but some stage definitions can be discussed. Despite the fact that the staging system is built on clinical data, the present analysis, which includes postsurgical data, confirms the similar survival of patients with T2N0M0 and T1N1M0. These results also stress the use of two separate substages, especially because these patients are offered surgery when possible.

21 keywords...

hide…