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Drug discovery today · Nov 2012
What is the most important approach in current drug discovery: doing the right things or doing things right?
- Thomas Elebring, Adrian Gill, and Alleyn T Plowright.
- AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. Thomas.Elebring@astrazeneca.com
- Drug Discov. Today. 2012 Nov 1; 17 (21-22): 1166-9.
AbstractDoing the right things or doing things right: what is the most important focus for current drug discovery to secure delivery of new drugs of sustainable value to patients, healthcare professionals and healthcare providers? Some of the challenges faced today in drug discovery are addressed here: the relationship between R&D speed, cost and quality; how selection of performance metrics can affect the quality of the R&D output; the importance of leadership and management; how process orientation can affect, for example, creativity and innovation; the importance of selecting the right pharmacologic target and the right chemical lead; and why the use of drug-target kinetic and thermodynamic data to drive lead selection and lead optimization could increase success rates.Copyright © 2012 Elsevier Ltd. All rights reserved.
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