• Biomarkers · Dec 2014

    Comparative Study

    Mortality prediction by acute kidney injury biomarkers in comparison with serum creatinine.

    • Takahiro Hiruma, Toshifumi Asada, Miyuki Yamamoto, Ryota Inokuchi, Takehiro Matsubara, Takeshi Ishii, Maki Sumida, Rei Isshiki, Kengo Mayumi, Eisei Noiri, Masaomi Nangaku, Naoki Yahagi, and Kent Doi.
    • Department of Emergency and Critical Care Medicine and.
    • Biomarkers. 2014 Dec 1; 19 (8): 646-51.

    ObjectivesTo investigate the performance of acute kidney injury (AKI) biomarkers for mortality prediction.Materials And MethodsCutoff values of urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-d-glucosaminidase (NAG) for AKI diagnosis in ICU were determined in the derivation cohort. The performance of these AKI biomarkers for mortality prediction was evaluated in the validation cohort with stratification of serum-creatinine based AKI diagnosis.ResultsMortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.ConclusionsThese AKI biomarkers can specifically detect high-risk patients among creatinine-base diagnosed AKI.

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