-
Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesia by continuous extradural infusion of bupivacaine and diamorphine.
- A Lee, D Simpson, A Whitfield, and D B Scott.
- Department of Anaesthetics, Royal Infirmary, Edinburgh.
- Br J Anaesth. 1988 Jun 1; 60 (7): 845-50.
AbstractThree solutions administered by continuous extradural infusion for postoperative analgesia were compared in a randomized, double-blind manner. All patients underwent major abdominal gynaecological surgery and received 0.125% bupivacaine in 0.9% saline, diamorphine in 0.9% saline (0.5 mg in 15 ml) or diamorphine mixed with 0.125% bupivacaine (0.5 mg in 15 ml), at a rate of 15 ml h-1. The bupivacaine-diamorphine mixture provided significantly superior analgesia compared with either bupivacaine or diamorphine alone. No major side effects were encountered.
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