• Clin Toxicol (Phila) · Dec 2014

    Case Reports

    Continuous renal replacement therapy circuit failure after antidote administration.

    • Jinwoo Jeong.
    • Department of Emergency Medicine, College of Medicine, Dong-A University , Seo-Gu, Busan , Republic of Korea.
    • Clin Toxicol (Phila). 2014 Dec 1; 52 (10): 1296-7.

    AbstractA 73-year-old man was transferred to the emergency department (ED). He was found unconscious in his house along with an empty 200-mL bottle of Basta(™), a herbicide containing 18% glufosinate. He was comatose with a Glasgow Coma Scale score of 3. As his blood pressure dropped to 60/30 mmHg despite fluids and norepinephrine, 20% intravenous fat emulsion product was injected. He experienced repeated cardiopulmonary arrests during his first 4 h in the ED. When the arrests occurred, standard cardiopulmonary resuscitation was performed, and boluses of fat emulsion were given. He was given a total of 1500 mL of 20% fat emulsion. In an attempt to correct the acidosis, continuous renal replacement therapy (CRRT) was started. Within 5 min of starting CRRT, the transmembrane pressure increased sharply and the machine stopped.

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