• Br J Anaesth · Mar 2003

    Randomized Controlled Trial Clinical Trial

    Propofol 1% versus propofol 2% in children undergoing minor ENT surgery.

    • M Pellégrini, C Lysakowski, L Dumont, A Borgeat, and E Tassonyi.
    • Division of Anaesthesiology, Department of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland. michel.pellegrini@hcuge.ch
    • Br J Anaesth. 2003 Mar 1; 90 (3): 375-7.

    BackgroundThe induction characteristics of propofol 1% and 2% were compared in children undergoing ENT surgery, in a prospective, randomized, double-blind study.MethodsOne hundred and eight children received propofol 1% (n=55) or 2% (n=53) for induction and maintenance of anaesthesia. For induction, propofol 4 mg kg(-1) was injected at a constant rate (1200 ml h(-1)), supplemented with alfentanil. Intubating conditions without the use of a neuromuscular blocking agent were scored.ResultsPain on injection occurred in 9% and 21% of patients after propofol 1% and 2%, respectively (P=0.09). Loss of consciousness was more rapid with propofol 2% compared with propofol 1% (47 s vs 54 s; P=0.02). Spontaneous movements during induction occurred in 22% and 34% (P=0.18), and intubating conditions were satisfactory in 87% and 96% (P=0.19) of children receiving propofol 1% or 2%, respectively. There were no differences between the two groups in respect of haemodynamic changes or adverse events.ConclusionsFor the end-points tested, propofol 1% and propofol 2% are similar for induction of anaesthesia in children undergoing minor ENT surgery.

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