• Diabetes Obes Metab · Oct 2014

    Comparative Study

    Mortality risk with sulphonylureas compared to metformin.

    • S E Holden and C J Currie.
    • Cochrane Institute of Public Health, School of Medicine, Cardiff University, Cardiff, UK.
    • Diabetes Obes Metab. 2014 Oct 1; 16 (10): 885-90.

    AbstractCurrent clinical guidelines in the USA and the UK recommend first-line glucose-lowering treatment with metformin monotherapy for glucose control in type 2 diabetes, where not contraindicated. Consequently, the proportion of people treated with sulphonylureas is decreasing. The purpose of this commentary is to discuss the risks and benefits associated with sulphonylurea monotherapy versus metformin monotherapy and the evidence that, in comparison with metformin, sulphonylureas cause increased harm to people with type 2 diabetes.© 2014 John Wiley & Sons Ltd.

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