• Am. J. Obstet. Gynecol. · Oct 2011

    Prediction of outcome in dichorionic twin pregnancies at 6-10 weeks' gestation.

    • George I Papaioannou, Argyro Syngelaki, Nerea Maiz, Jackie A Ross, and Kypros H Nicolaides.
    • Fetal Medicine Unit, King's College Hospital, London, England, UK. papaioannougk@gmail.com
    • Am. J. Obstet. Gynecol. 2011 Oct 1; 205 (4): 348.e1-5.

    ObjectiveThe objective of the study was to predict the outcome of dichorionic (DC) twin pregnancies at 6-10 weeks' gestation from intertwin discordance in crown-rump length (CRL), heart rate (HR), and gestational sac diameter (GSD).Study DesignIntertwin discordance in CRL, HR, and GSD, was compared in 3 groups of DC twin pregnancies with 2 live embryos at 6-10 weeks. In one group, there were 2 live births (n = 174), in another 1 live birth (n = 24), and in a third group there were no live births (n = 33). Regression analysis was used to determine the predictors of outcome.ResultsSignificant contributors to the prediction of 1 intrauterine death were discordance in CRL and GSD. The only predictor of 2 deaths was discordance in CRL. Detection rates of screening for single or double death, at 10% false-positive rate, were 79.2% and 27.3%, respectively.ConclusionIn DC twins, intertwin discordance in CRL and GSD at 6-10 weeks can predict outcome.Copyright © 2011 Mosby, Inc. All rights reserved.

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