• Eur. J. Appl. Physiol. · Aug 2011

    Strong ion reserve: a viewpoint on acid base equilibria and buffering.

    • Michalis Agrafiotis.
    • Second Department of Intensive Care Medicine, "Georgios Papanikolaou" General Hospital of Thessaloniki, 57010, Exochi, Greece. m.agrafiotis@gmail.com
    • Eur. J. Appl. Physiol. 2011 Aug 1; 111 (8): 1951-4.

    AbstractEvidence suggests that strong ions can exist reversibly bound to proteins in a pH-dependent manner and that they can be recruited into the biological solution, modulating its strong ion difference in a process that opposes the acid base disturbances imposed on the system. These recruitable strong ions represent the solution's 'strong ion reserve'. The physiologic [corrected] role of these protein-bound strong ions [corrected] in the buffering of acid base disorders is discussed.

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