• J. Cardiothorac. Vasc. Anesth. · Jan 2015

    Reversal of Heparin After Cardiac Surgery: Protamine Titration Using a Statistical Model.

    • Fredrik Ödling Davidsson, Daniel Johagen, Micael Appelblad, and Staffan Svenmarker.
    • Department of Surgical & Perioperative Science, Heart Centre Umeå University, Umeå, Sweden.
    • J. Cardiothorac. Vasc. Anesth. 2015 Jan 1;29(3):710-4.

    ObjectiveTo establish a statistical model for determination of protamine dose in conjunction with cardiopulmonary bypass.DesignProspective.SettingUniversity hospital.ParticipantsNinety consecutive cardiac surgical patients.InterventionsNone.Measurements And Main ResultsA series of clinically oriented variables were introduced into a statistical model for projection of the protamine dose after cardiopulmonary bypass. The following significant predictors were identified using multivariable regression analysis: The patient's body surface area, the administered dose of heparin, heparin clearance, and the preoperative platelet count. The statistical model projected the protamine dose within 3±23 mg of the point-of-care test used as reference.ConclusionProtamine dosing based on statistical modeling represents an alternative to point-of-care tests.Copyright © 2015 Elsevier Inc. All rights reserved.

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