• V Pettilä and E Tiula.
• Department of Surgery, and Helsinki University Central Hospital, Espoo, Finland. ville.pettila@helsinki.fi
• Clin Nephrol. 2001 Oct 1; 56 (4): 324-31.

AimsThe objective was to study the effects of daily intermittent on-line predilution hemodiafiltration (IHDF) on laboratory parameters, and on multiple organ dysfunction score (MODS), compared with intermittent hemodialysis (IHD).MaterialDesignProspective, randomized, non-blinded study.SettingA 10-bed medical-surgical intensive care unit in a tertiary-care hospital, 39 patients with acute renal failure.MethodsIHDF or IHD was performed daily with the same equipment: AK 100 Ultra, and Polyflux 17 hemodiafilter up to day 30. Laboratory parameters, MODS, survived days free of acute renal failure treatment, number and complications of treatments, and hospital mortality were recorded.ResultsEffects of treatments were equal as to urea reduction ratio and changes in serum creatinine, calcium, phosphate and bicarbonate. Survived days free of acute renal failure treatment were fewer for the IHDF (4.8 vs. 10.3 days for the IHD, p = 0.036, Mann-Whitney test). The overall hospital mortality of all patients was 34% (95% CI 18-50%).ConclusionsThis study demonstrated equal control of azotemia, acidosis, and calcium-phosphate balance in both treatment groups with no treatment-specific complications of IHDF.

32 keywords...

hide…