• Vox sanguinis · Jan 2000

    Randomized Controlled Trial Comparative Study Clinical Trial

    Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time.

    • R G Lerner, J Nelson, E Sorcia, K Grima, R R Kancherla, C M Zarou-Naimo, and J C Pehta.
    • Hematology Section, Department of Medicine, Valhalla, N.Y., USA.
    • Vox Sang. 2000 Jan 1; 79 (3): 161-7.

    ObjectivesTo compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).MethodsA randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to Results45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to ConclusionNo clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.Copyright 2000 S. Karger AG, Basel

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