• Resuscitation · Jul 2015

    Prognostic value of reduced discrimination and oedema on cerebral computed tomography in a daily clinical cohort of out-of-hospital cardiac arrest patients.

    • Sandra Langkjær, Christian Hassager, Jesper Kjaergaard, Idrees Salam, Jakob Hartvig Thomsen, Freddy K Lippert, Michael Wanscher, Lars Køber, Niklas Nielsen, and Helle Søholm.
    • Department of Cardiology 2142, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    • Resuscitation. 2015 Jul 1; 92: 141-7.

    PurposeAssessment of prognosis after out-of-hospital cardiac arrest (OHCA) is challenging. Cerebral computed tomography (cCT) scans are widely available, but the use in prognostication of comatose OHCA-patients is unclear. We evaluated the prognostic value of cCT in a clinical cohort of OHCA-patients.MethodA total of 1120 consecutive OHCA-patients with cardiac aetiology and successful or on-going resuscitation at hospital arrival were included (2002-2011). Utstein-criteria for registration of pre-hospital data and review of patient-charts for post-resuscitation care including cCT results were used. The primary endpoint was 30-day mortality analysed by log-rank and multivariate Cox-regression analyses.ResultsA cCT scan was performed in 341(30%) of the clinical OHCA-cohort, and an early CT (<24h) was performed in 188 patients. The early CT was found 'normal' in 163(89%) and with reduced discrimination in 7(4%) of patients, which was independently associated with higher 30-day mortality compared with OHCA-patients with an early cCT (HR(adjusted) = 3.5 (95%CI: 1.0-11.5), p = 0.04). A late CT (≥ 24 h) was performed in 153 patients in a median of 3 days (IQR: 2-5) and was 'normal' in 89(60%), 'cerebral bleeding' in 4(3%), 'new cerebral infarction' in 10(7%), and 'reduced discrimination between white and grey matter and/or oedema' in 45(30%) patients. 'Reduced discrimination and/or oedema' by late cCT was independently associated with higher 30-day mortality compared to patients with a normal late CT (HR(adjusted) = 2.6 (95%CI: 1.4-4.8, p = 0.002).ConclusionOur observations suggest that a cCT may be useful as part of the neurological prognostication in patients with OHCA. 'Reduced discrimination between white and grey matter and/or oedema' on cCT was independently associated with a poor prognosis.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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