• Crit Care · Jan 2015

    Review

    Neuroprotection in acute brain injury: an up-to-date review.

    • Nino Stocchetti, Fabio S Taccone, Giuseppe Citerio, Paul E Pepe, Peter D Le Roux, Mauro Oddo, Kees H Polderman, Robert D Stevens, William Barsan, Andrew I R Maas, Geert Meyfroidt, Michael J Bell, Robert Silbergleit, Paul M Vespa, Alan I Faden, Raimund Helbok, Samuel Tisherman, Elisa R Zanier, Terence Valenzuela, Julia Wendon, David K Menon, and Jean-Louis Vincent.
    • Department of Physiopathology and Transplant, Milan University, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy. stocchet@policlinico.mi.it.
    • Crit Care. 2015 Jan 1;19:186.

    AbstractNeuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

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