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Korean J Anesthesiol · Dec 2011
Dilution and slow injection reduces the incidence of rocuronium-induced withdrawal movements in children.
- Young Hee Shin, Chung Su Kim, Jong-Hwan Lee, Woo Seog Sim, Justin Sangwook Ko, Hyun Sung Cho, Hui Yeon Jeong, Hye Won Lee, and Sang Hyun Kim.
- Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Korean J Anesthesiol. 2011 Dec 1; 61 (6): 465-9.
BackgroundThe aim of this study was to evaluate whether slow injection of diluted rocuronium could reduce rocuronium-induced withdrawal movements effectively in children.MethodsAfter loss of consciousness, rocuronium 0.6 mg/kg was administered into 171 children according to the pre-assigned groups as follows: Group CF, injection of non-diluted rocuronium over 5 seconds; Group CS, injection of non-diluted rocuronium over 1 minute; Group DF, injection of diluted rocuronium (10 times) over 5 seconds; Group DS, injection of diluted rocuronium over 1 minute. An investigator who was blind to the injection techniques recorded patient movements followed by rocuronium injection.ResultsThe incidence of withdrawal movement in Group CF was highest among the groups (all P < 0.0001). Moreover, withdrawal movement was less frequently observed in Group DS than in Groups CS and DF (P = 0.021 and P = 0.007, respectively).ConclusionsSlow injection of diluted rocuronium reduced the incidence of withdrawal movements in children.
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