• J Nath, J Hodson, S W Canbilen, J Al Shakarchi, N G Inston, A Sharif, and A R Ready.
• Departments of Renal Surgery, University Hospital Birmingham NHS Trust, Birmingham, UK.
• Br J Surg. 2016 Aug 1; 103 (9): 1230-6.

BackgroundThe aim of the present study was to determine the effects of cold ischaemia time (CIT) on living donor kidney transplant recipients in a large national data set.MethodsData from the National Health Service Blood and Transplant and UK Renal Registry databases for all patients receiving a living donor kidney transplant in the UK between January 2001 and December 2014 were analysed. Patients were divided into three groups depending on CIT (less than 2 h, 2-4 h, 4-8 h). Risk-adjusted outcomes were assessed by multivariable analysis adjusting for discordance in both donor and recipient characteristics.ResultsOutcomes of 9156 transplants were analysed (CIT less than 2 h in 2662, 2-4 h in 4652, and 4-8 h in 1842). After adjusting for confounders, there was no significant difference in patient survival between CIT groups. Recipients of kidneys with a CIT of 4-8 h had excellent graft outcomes, although these were slightly inferior to outcomes in those with a CIT of less than 2 h, with risk-adjusted rates of delayed graft function of 8·6 versus 4·3 per cent, and 1-year graft survival rates of 96·2 versus 97·1 per cent, respectively.ConclusionThe detrimental effect of prolonging CIT for up to 8 h in living donation kidney transplantation is marginal.© 2016 BJS Society Ltd Published by John Wiley & Sons Ltd.

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