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- C Becker, A Luginbühl, U Pittl, and R Schlienger.
- Klinische Pharmakologie & Toxikologie, Universitätsspital Basel, Medizinische Universitätsklinik, Kantonsspital Liestal. beckerc@uhbs.ch
- Praxis (Bern 1994). 2005 Sep 7; 94 (36): 1402-7.
AbstractLactic acidosis is a serious clinical situation associated with a high case fatality rate. Lactic acidosis is particularly found in conditions with an insufficient supply of oxigen in the tissue. Other causes for lactic acidosis can be hepatic or renal insufficiency. For the therapy of overweight patients with type 2 diabetes metformin is the first choice if diet and physical training have been ineffective. Metformin, however, has the potential to increase serumlactate. Therefore its ability to cause lactic acidosis is controversely discussed. We present a 64-year-old female patient with metformin-associated lactic acidosis. She had several pre-existing risk factors to develop a lactic acidosis. On her referral to the hospital she suffered from acute renal failure which is considered to be a contraindication for the use of metformin.
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