• M B Callan, R T Patel, A H Rux, S Bandyopadhyay, A N Sireci, P A O'Donnell, T Ruane, T Sikora, K Marryott, B S Sachais, and E A Hod.
• Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Vox Sang. 2013 Nov 1; 105 (4): 319-27.

Background And ObjectivesStudies in mice suggest that rapid transfusions of red blood cells (RBCs), refrigerator stored for longer durations, induce a pro-inflammatory cytokine response. Studies in human neonates confirm these findings; however, to date, adult human studies have failed to replicate these findings. We used healthy research dogs to begin to examine the factors affecting the cytokine response to transfusion.Materials And MethodsIn a prospective study, healthy dogs were randomized for two autologous packed RBC transfusions after 7 (i.e. 'fresh') and 28 (i.e. 'old') days of storage, or after 28 and 7 days of storage, with or without prestorage leucoreduction (LR).ResultsNo significant differences were observed between LR and non-LR transfusions for all circulating analytes measured following transfusion. A pro-inflammatory cytokine response, exemplified by monocyte chemoattractant protein-1, was observed 6 h after only old RBC transfusions, irrespective of infusion rate (P < 0·001). This response was accompanied by increased neutrophil counts (P < 0·001) and decreased platelet counts (P < 0·001).ConclusionIn healthy dogs, old RBC transfusions induce inflammation, which is unaffected by infusion rate.© 2013 International Society of Blood Transfusion.

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