• Annals of neurology · Mar 1991

    Case Reports

    Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy.

    • L Palm, G Blennow, and L Wetterberg.
    • Department of Pediatrics, University Hospital, Lund, Sweden.
    • Ann. Neurol. 1991 Mar 1; 29 (3): 336-9.

    AbstractA 9-year-old, blind boy with severe mental retardation with a chronic sleep/wake disturbance had a circadian rhythm of 24.75 hours and an internal desynchronization of the endogenous rhythms. Treatment with oral melatonin given at 6 PM induced a regular sleep/wake pattern. Melatonin, in this patient, convincingly entrained the endogenous rhythm to the appropriate chronological 24-hour day.

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