• Prashant N Mohite, Bartlomiej Zych, Anton Sabashnikov, Aron-Frederik Popov, Diana Garcia-Saez, Nikhil P Patil, Achim Koch, Mohamed Zeriouh, Parwis B Rahmanian, Dhruva Dhar, Mohamed Amrani, Toufan Bahrami, Fabio DeRobertis, Martin Carby, Anna Reed, and Andre R Simon.
• Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Harefield, Middlesex, UK.
• Clin Transplant. 2016 Apr 1; 30 (4): 421-8.

BackgroundLimited data are available about lung transplantation (LTx) from donors suffering cardiac arrest (CA) prior to actual donation.MethodsA retrospective analysis of LTx performed between January 2007 and September 2012 was done with the focus on CA in donors. The recipients were grouped depending on the history of donor CA and CA duration (downtime) as: No cardiac arrest ("NoCA"), CA downtime less than 20 min ("CA < 20"), and CA downtime equal to or more than 20 min ("CA > 20"). Early and mid-term outcomes after LTx were compared among the three groups.ResultsA total of 237 LTx were performed during the study period. One hundred eighty-eight patients received organs from "NoCA" donors, 25 from "CA < 20" donors, and 24 patients from "CA > 20" donors. There was a trend toward better overall cumulative survival in both CA groups (log rank p = 0.076) whereas the survival in the "CA > 20" group was significantly better than in the "NoCA" group in the subgroup analysis (log rank p = 0.045). Freedom from bronchiolitis obliterans syndrome (BOS) also increased with increase in CA duration, although it did not reach statistical significance.ConclusionsTransplantation of lungs from donors with a history of CA is safe and feasible. Longer duration of cardiac arrest may improve the outcomes after the LTx in terms of survival and freedom from BOS.© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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