• J Trauma · Aug 2004

    Comparative Study

    Laser Doppler flow and brain tissue PO2 after cortical impact injury complicated by secondary ischemia in rats treated with arginine.

    • Donna R Mendez, Leela Cherian, and Claudia S Robertson.
    • Department of Pediatrics/Emergency Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. drmendez@texaschildrenshospital.org
    • J Trauma. 2004 Aug 1; 57 (2): 244-50.

    BackgroundTraumatic brain injury (TBI) makes the brain susceptible to secondary insults such as ischemia. This study tested the hypothesis that L-arginine would increase regional CBF (rCBF) and brain tissue PO2 (PbtO2) at the injury site.MethodsA secondary insult model was employed in rodents. rCBF was measured with laser doppler flowmetry (LDF) and PbtO2 with a PO2 catheter at the impact site. Animals were randomized to receive L-arginine, D-arginine or saline intravenously, 5 minutes after impact.ResultsIn animals who received L-arginine, the percentage rCBF from baseline (%CBF) was higher at the impact site after impact (p < 0.001), during bilateral carotid occulation (BCO) (p = 0.001) and during reperfusion (p = 0.032). In contrast, PbtO2 was not significantly increased throughout the experiment for the L-arginine group.ConclusionsAdministration of L-arginine increased rCBF in the injured brain tissue, and resulted in better preservation of CBF during BCO than D-arginine and saline.

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