• Masui · Sep 2010

    Review

    [Preoperative management of malignant hyperthermia].

    • Takako Migita and Masashi Kawamoto.
    • Department of Anesthesiology and Critical Care, Hiroshima University and Graduate School, Hiroshima 734-8551.
    • Masui. 2010 Sep 1; 59 (9): 1138-41.

    AbstractMalignant hyperthermia (MH) is a potentially fatal complication of general anesthesia following exposure to a depolarizing muscle relaxant and/or volatile anesthetics. MH is inherited as autosomal dominant and is thought to result from disordered Ca2+ regulation by the sarcoplasmic reticulum of the skeletal muscle. The mortality is still approximately 15% in Japan. It is difficult to diagnose by usual examinations preoperatively. Therefore, early detection, prompt treatment, discontinuation of triggering agents, and sufficient administration of dantrolene are needed.

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