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- Juanita Olano, Beatriz López, Alejandro Reyes, María del Pilar Lemos, Nidia Correa, Patricia Del Portillo, Lucia Barrera, Jaime Robledo, Viviana Ritacco, and María Mercedes Zambrano.
- Corporación Corpogen, Carrera 5 No. 66A-34, Bogotá, Colombia.
- Tuberculosis (Edinb). 2007 Nov 1; 87 (6): 502-8.
AbstractThe analysis of the DNA repair genes ogt and ung was carried out in 117 Mycobacterium tuberculosis clinical isolates from Argentina and Colombia in order to explore correlation between mutations in these genes and multi-drug resistance. With the exception of two Beijing family isolates, the rest of the strains harbored either two wild-type or two mutant alleles with identical single nucleotide polymorphisms (SNPs) in each gene (ogt44 and ung501). These ogt44 and ung501 mutations were not associated with multi-drug resistance and occurred simultaneously in circulating Haarlem genotype M. tuberculosis strains. We therefore propose the use of these markers as tools in phylogenetic and epidemiologic studies.
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