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Randomized Controlled Trial Comparative Study Clinical Trial
Ventilatory effects of eltanolone during induction of anaesthesia: comparison with propofol and thiopentone.
- H J Spens and G B Drummond.
- Department of Anaesthetics, Royal Infirmary, Edinburgh.
- Br J Anaesth. 1996 Aug 1; 77 (2): 194-9.
AbstractWe recorded the ventilatory effects of eltanolone 0.75 mg kg-1, propofol 2.5 mg kg-1 and thiopentone 4 mg kg-1 at induction of anaesthesia in 76 unpremedicated patients, aged 18-65 yr. Measurements were made using a pneumotachograph incorporated between a close-fitting face mask and a T-piece delivering 35% oxygen. Eltanolone caused significantly less apnoea than propofol (incidence 57% vs 100%) and less reduction in ventilation than propofol (median maximum decrease 4.8 vs 7.8 litre min-1), but the differences between eltanolone and thiopentone were smaller and generally not significant. Ventilatory frequency was maintained well in the eltanolone group.
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