• Br J Anaesth · Jul 1991

    Effect of thiopentone, etomidate and propofol on systemic vascular resistance during cardiopulmonary bypass.

    • F Boer, J G Bovill, P Ros, and H van Ommen.
    • Department of Anaesthesiology, University Hospital Leiden, The Netherlands.
    • Br J Anaesth. 1991 Jul 1; 67 (1): 69-72.

    AbstractWe have studied the effect of thiopentone, etomidate and propofol on systemic vascular resistance (SVR) during cardiopulmonary bypass with constant pump flow in 30 patients undergoing elective coronary artery bypass surgery. SVR decreased to 78% of control values after thiopentone 4 mg kg-1, to 72% of control after etomidate 0.3 mg kg-1, and to 68% of control after propofol 2 mg kg-1; it returned to control values 10 min after administration of thiopentone and propofol and 7 min after administration of etomidate. Analysis of variance showed that there were no significant differences in the changes in SVR between the groups.

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