• Zhen-jie Hu, Li-xia Liu, Li-xiao Sun, and Yong Li.
• ICU, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei China.
• Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Apr 1; 17 (4): 234-7.

ObjectiveTo study the influence of continuous veno-venous hemofiltration (CVVH) on the hemodynamics and the prognosis of sheep with endotoxic shock.MethodsEndotoxic shock was induced by intravenous infusion of lipopolysaccharide, L-2880, to sheep, and the animals were randomly divided to control group (NHF, endotoxin only) or treatment group (HF, endotoxin+CVVH). In the latter groups a zero-balanced CVVH was instituted with an ultrafiltration rate of 40 ml x kg(-1) x h(-1) and a blood flow rate of 80 ml/min. The hemodynamic parameters were monitored.ResultsAfter the administration of endotoxin, the mean arterial pressure (MAP) was decreased significantly, while mean pulmonary artery pressure (MPAP) and cardiac index (CI) increased significantly in both groups (P<0.05 or P<0.01). With CVVH, MAP and stroke volume (SV) were increased significantly, and were significantly higher than that of NHF group (P<0.05 or P<0.01). CI declined progressively in NHF group and significantly lower than that of HF group, in which there was no significant change(P<0.05). No significant difference in MPAP was found between two groups (P>0.05). Moreover, plasma lactate levels were lower in NHF group than in HF group (P<0.05). After 5 hours, the sheep in HF group all survived, and 2 sheep of NHF group died.ConclusionIntravenous infusion of endotoxin could produce endotoxic shock in sheep. CVVH was shown to have a beneficial effect on the hemodynamics, and it gave a better prognosis in endotoxic, indicating that it might be important method to treat endotoxic shock.

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