• Haizhao Song, Jia Lai, Qiong Tang, and Xiaodong Zheng.
• College of Biosystems Engineering and Food Science, Zhejiang university, Hangzhou, PR China; Fuli Institute of Food Science, Zhejiang University, Hangzhou, PR China; Zhejiang Key Laboratory for Agro-food Processing, Zhejiang University, Hangzhou, PR China.
• Nutr Res. 2016 Jul 1; 36 (7): 710-8.

AbstractNonalcoholic fatty liver disease is one of the most common complications of obesity. Mulberry is an important source of phytochemicals, such as anthocyanins, polyphenols and flavonoids, which are related to its antioxidant activity. In this study, we developed a hypothesis that mulberry exerted beneficial effects on metabolic disorders and evaluated the influence of the mulberry ethanol extract (MEE) on high-fat diet-induced hepatic steatosis and insulin resistance in mice. Thirty-six male C57BL/6J mice were assigned into 3 groups and fed either a low-fat diet or a high-fat diet with or without supplementation with MEE. Our results showed that administration of MEE reduced diet-induced body weight gain, improved high-fat diet-induced hepatic steatosis and adipose hypertrophy, alleviated insulin resistance, and improved glucose homeostasis. Analysis of hepatic gene expression indicated that MEE treatment changed the expression profile of genes involved in lipid and cholesterol metabolism. In conclusion, the present study demonstrated that MEE supplementation protected mice from high-fat diet-induced obesity, hepatic steatosis, and insulin resistance. Moreover, the protective effects of MEE were associated with the induction of fatty acid oxidation and decreased fatty acid and cholesterol biosynthesis.Copyright © 2016 Elsevier Inc. All rights reserved.

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