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  • Exp Clin Transplant · Feb 2012

    Comparative Study

    Cystatin C as a marker of glomerular filtration rate in voluntary kidney donors.

    • Krishnaswamy Jaisuresh, Raj Kumar Sharma, Sonia Mehrothra, Anupma Kaul, Dharmendra Singh Badauria, Amit Gupta, Narayan Prasad, and Apoorva Jain.
    • Department of Nephrology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. drjaisuresh@gmail.com
    • Exp Clin Transplant. 2012 Feb 1; 10 (1): 14-7.

    ObjectivesCystatin C is emerging as an endogenous marker of glomerular filtration rate. This study sought to assess the usefulness of serum cystatin C as a marker of glomerular filtration rate in comparison with serum creatinine and serum creatinine-based glomerular filtration rate estimations in voluntary kidney donors.Materials And MethodsSerum cystatin C and serum creatinine were estimated in 35 voluntary kidney donors. Glomerular filtration rate was estimated using: (1) Cockcroft-Gault method normalized to 1.73 m(2) of body surface area, (2) 4-variable Modification of Diet in Renal Diseases formula, and (3) (99m)Tc-DTPA double plasma sampling method. Glomerular filtration rate-double plasma sampling method was used as a reference value. Results were expressed as means ± SD.ResultsThe mean age of the participants was 44.23 ± 8.61 years old (19 women, 16 men). The mean serum creatinine was 0.83 ± 0.14 mg/dL, and the mean serum cystatin C was 0.71 ± 0.12 mg/L. Serum cystatin C showed significant correlation with serum creatinine (r = 0.864; P < .001). Glomerular filtration rate-MDRD showed the strongest correlation with glomerular filtration rate double plasma sampling method (r = 0.93; P < .001), followed by glomerular filtration rate-Cockcroft-Gault (r = 0.76; P < .001 ), serum creatinine (r = - 0.68; P < .001), and serum cystatin C (r = - 0.59; P < .001). The mean serum cystatin C values were 22.6% higher in men than in women. There was a significant correlation of serum cystatin C with glomerular filtration rate-Cockcroft-Gault (r = - 0.50; P = .002 ), glomerular filtration rate-MDRD (r = - 0.59; P < .001 ), and glomerular filtration rate-double plasma sampling method (r = - 0.59; P < .001 ).ConclusionsSerum cystatin C is an optimal marker of glomerular filtration rate in voluntary kidney donors.

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