• Robert E Steinert, Ralph Peterli, Sylvia Keller, Anne C Meyer-Gerspach, Jürgen Drewe, Thomas Peters, and Christoph Beglinger.
• Department of Biomedicine and Division of Gastroenterology, University Hospital Basel, Switzerland; Discipline of Medicine, University of Adelaide, Level 6 Eleanor Harrald Building, Royal Adelaide Hospital, Frome Road, Adelaide, 5005, South Australia.
• Obesity (Silver Spring). 2013 Dec 1; 21 (12): E660-8.

ObjectiveIncreased delivery of bile acid salts (BA) to distal L-cells and altered TGR5 receptor activation may contribute to the early and substantial increases in gut peptide secretion seen after bariatric surgery. To further elucidate a potential role of BA in the secretion of GLP-1 and PYY, we analyzed plasma BA concentrations in 14 morbidly obese patients undergoing gastric bypass or sleeve gastrectomy in a prospective, randomized 1-year trial.Design And MethodsPatients received a standard test meal and blood was collected before and after eating, prior to, and 1 week, 3 months, and 12 months after surgery.ResultsPre-surgery, basal BA concentrations were significantly lower in bariatric patients than in healthy controls. One year post-surgery, bariatric patients expressed variably increased BA concentrations (gastric bypass patients ∼2 fold increase, P ≤ 0.05). However, whereas in both patient groups, marked increases in GLP-1 and PYY and improved glycemic control was seen already 1 week and 3 months post-surgery, changes in plasma BA followed a different pattern: basal and postprandial plasma BA concentrations increased much slower, more progressively with significant increases only 1-year post-surgery.ConclusionsBased on these findings, BA do not appear to be key mediators of the early increase in GLP-1 and PYY response in post-bariatric patients.Copyright © 2013 The Obesity Society.

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