• Li-hui Miao, Qing Song, Hui Liu, Liang Pan, and Fei-hu Zhou.
• Department of Critical Care Medicine, General Hospital of Chinese PLA, Beijing 100853, China.
• Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Apr 1; 25 (4): 238-41.

ObjectiveTo investigate the value of serum interleukin-6 (IL-6) level as a prognostic indicator in severe acute pancreatitis (SAP) patients.MethodsData of 62 cases of SAP admitted to Department of Critical Care Medicine from January 2006 to September 2012 were retrospectively analyzed. They were divided into two groups: non-survivor group (n=15) and survivor group (n=47). Serum levels of IL-6 at 24, 48, 72 hours after admission were compared between two groups. Correlation between IL-6 value and acute physiology and chronic health evaluation II (APACHE II) score and CT severity index (CTSI) at 48 hours were analyzed. The receiver-operating characteristic curve (ROC curve) was plotted at 48 hours to analyze the accuracy of IL-6 value as a prognostic indicator in the initial stage of SAP.ResultsThe IL-6 values were elevated obviously followed by a lowering in non-survivor group. However, it continued to decrease gradually in survivor group. The IL-6 values of non-survivor group were significantly higher than those of survivor group at 48 hours and 72 hours after admission (545.5 ± 265.7 ng/L vs. 147.2 ± 107.0 ng/L, 243.0 ± 133.6 ng/L vs. 119.0 ± 69.5 ng/L, both P<0.01). IL-6 ROC had an area under curve (AUC) of 0.930 at 48 hours. In both groups, IL-6 values and APACHEII score showed a positive correlation (r=0.930, P=0.003; r=0.964, P=0.000), and also between IL-6 values and CTSI (r=0.915, P=0.000; r=0.921, P=0.005) at 48 hours.ConclusionIL-6 can be a useful indicator of the prognosis in the initial stage of SAP (48 hours).

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