• Anesthesiology · Aug 2016

    A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.

    • Daniel Diaz-Gil, Friederike Haerter, Shane Falcinelli, Shweta Ganapati, Gaya K Hettiarachchi, Jeroen C P Simons, Ben Zhang, Stephanie D Grabitz, Ingrid Moreno Duarte, Joseph F Cotten, Katharina Eikermann-Haerter, Hao Deng, Nancy L Chamberlin, Lyle Isaacs, Volker Briken, and Matthias Eikermann.
    • From the Anesthesia, Critical Care and Pain Medicine (D.D.-G., F.H., J.C.P.S., S.D.G., I.M.D., J.F.C., M.E.), Radiology (K.E.-H.), and Biostatistics (H.D.), Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Cell Biology and Molecular Genetics (S.F., G.K.H., V.B.) and Chemistry and Biochemistry (S.G., B.Z., L.I.), University of Maryland, College Park, Maryland; Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (N.L.C.); and Anesthesia and Critical Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.E.).
    • Anesthesiology. 2016 Aug 1; 125 (2): 333-45.

    BackgroundCalabadion 2 is a new drug-encapsulating agent. In this study, the authors aim to assess its utility as an agent to reverse general anesthesia with etomidate and ketamine and facilitate recovery.MethodsTo evaluate the effect of calabadion 2 on anesthesia recovery, the authors studied the response of rats to calabadion 2 after continuous and bolus intravenous etomidate or ketamine and bolus intramuscular ketamine administration. The authors measured electroencephalographic predictors of depth of anesthesia (burst suppression ratio and total electroencephalographic power), functional mobility impairment, blood pressure, and toxicity.ResultsCalabadion 2 dose-dependently reverses the effects of ketamine and etomidate on electroencephalographic predictors of depth of anesthesia, as well as drug-induced hypotension, and shortens the time to recovery of righting reflex and functional mobility. Calabadion 2 displayed low cytotoxicity in MTS-3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium-based cell viability and adenylate kinase release cell necrosis assays, did not inhibit the human ether-à-go-go-related channel, and was not mutagenic (Ames test). On the basis of maximum tolerable dose and acceleration of righting reflex recovery, the authors calculated the therapeutic index of calabadion 2 in recovery as 16:1 (95% CI, 10 to 26:1) for the reversal of ketamine and 3:1 (95% CI, 2 to 5:1) for the reversal of etomidate.ConclusionsCalabadion 2 reverses etomidate and ketamine anesthesia in rats by chemical encapsulation at nontoxic concentrations.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    This article appears in the collection: What are Calabadions? Can they replace sugammadex?.


    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..