• Hua Gong, Li-na Zhang, Hong-wei Cai, Yan-jin Wang, and Yong-hong Hou.
• Department of Anesthesiology and Intensive Care Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. gongh7411@hotmail.com
• Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Oct 1; 32 (5): 850-4.

ObjectiveTo investigate the effect of different tidal volume ventilations on the amount of atelectasis during general anesthesia.MethodsTwenty adults, ASA physical status I and status II patients, who were scheduled for elective excision of intracranial lesion were randomly divided into 2 groups: Group TV (traditional tidal volume ventilation, 10 mL/kg) and Group LV (low tidal volume ventilation, 6 mL/kg). Atelectasis, as determined by CT and artery blood gas (ABG) analysis, was measured before the anesthesia, after the tracheal intubation, and at the end of the operation, respectively. Respiratory mechanical parameters were measured at 30, 120, and 240 min after the intubation.ResultsAfter the tracheal intubation, CT scan showed obvious atelectasis in both groups. The atelectasis area was(4.35+/-2.15)cm2 (3.12%+/-1.94%) in the TV group and (4.80+/-2.45)cm2 (3.89%+/-2.11%) in the LV group, with a nonsignificant difference between the 2 groups. At the end of the operation, there was no significant increase in the amount of atelectasis between and within the 2 groups. Artery blood gas analysis showed no difference after the tracheal intubation and at the end of the operation in either group. Ppeak, Pplat, Pmean and lung compliance(Cst)were significantly higher in the TV group than those in the LV group.ConclusionLow tidal volume(6 mL/kg) ventilation is more feasible during general anesthesia in patients with healthy lungs, and it does not increase the atelectasis and impairment of gas exchange.

17 keywords...

hide…