• Can Fam Physician · Mar 1998

    Is topical tretinoin safe during the first trimester?

    • L Shapiro, A Pastuszak, G Curto, and G Koren.
    • Hospital for Sick Children, Toronto.
    • Can Fam Physician. 1998 Mar 1; 44: 495-8.

    AbstractQUESTIONOne of my patients conceived while using a topical tretinoin preparation for acne. I know this drug is related to Accutane, which is teratogenic. How should I advise her?ANSWERAvailable evidence suggests that topical tretinoin does not increase teratogenic risk in humans.

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