• Rev Neurol France · Sep 2001

    Comparative Study

    [Treatment of remitting forms of multiple sclerosis].

    • C Lubetzki.
    • Fédération de Neurologie, INSERM U-495, Hôpital de la Salpêtrière, 75013 Paris. catherine.lubetzki@psl.ap-hop-paris.fr
    • Rev Neurol France. 2001 Sep 1; 157 (8-9 Pt 2): 996-1000.

    AbstractDisease-modifying treatments in multiple sclerosis emerged during the last few years, concerning mainly relapsing-remitting forms of the disease. They are essentially represented by beta-interferons. beta-interferons reduce relapse rate, achieving about 30 p. cent, and have an effect on brain lesions detected on MRI. They are indicated for use in ambulatory patients with relapsing-remitting multiple sclerosis characterized by at least 2 attacks of neurological dysfunction over the preceding 2 (or 3)-year period. Questions and controversies still remain concerning dose-response effect, early initiation and duration of treatment. Copolymer, which has a different mechanism of action, also decreases frequency of relapses, and the magnitude of the clinical effect is similar to beta-interferon. Copolymer is indicated for use in patients with relapsing-remitting multiple sclerosis, having either an intolerance or a contra-indication to beta-interferon.

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